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HomoloGene:31141. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TERT,  H.sapiens
telomerase reverse transcriptase
    NP_937983.2
1132 aa
   TERT,  P.troglodytes
telomerase reverse transcriptase
    XP_003950543.1
1135 aa
   TERT,  C.lupus
telomerase reverse transcriptase
    NP_001026800.1
1123 aa
   TERT,  B.taurus
telomerase reverse transcriptase
    NP_001039707.1
1125 aa
   Tert,  M.musculus
telomerase reverse transcriptase
    NP_033380.1
1122 aa
   Tert,  R.norvegicus
telomerase reverse transcriptase
    NP_445875.1
1125 aa
   TERT,  G.gallus
telomerase reverse transcriptase
    NP_001026178.1
1346 aa
   tert,  X.tropicalis
telomerase reverse transcriptase
    XP_004915405.1
1214 aa
   tert,  D.rerio
telomerase reverse transcriptase
    NP_001077335.1
1098 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Aplastic anemia, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Pulmonary alveolar proteinosis revealing a telomerase disease.
Marchand-Adam S, et al. Am J Respir Crit Care Med 188, 402-4 (2013).
Frequency of TERT promoter mutations in human cancers.
Vinagre J, et al. Nat Commun 4, 2185 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RVT_1 (pfam00078)
  Reverse transcriptase (RNA-dependent DNA polymerase).
RT_like (cl02808)
  RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
Telomerase_RBD (cl13446)
  Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tert includes H.sapiens TERT and R.norvegicus Tert.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (3 transcripts, 3 species)
Eudicotyledons - eudicots (2 transcripts, 2 species)

 

 

 

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