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HomoloGene:709. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   PDE3B,  H.sapiens
phosphodiesterase 3B, cGMP-inhibited
1112 aa
   PDE3B,  P.troglodytes
phosphodiesterase 3B, cGMP-inhibited
1052 aa
   PDE3B,  M.mulatta
phosphodiesterase 3B, cGMP-inhibited
1117 aa
   PDE3B,  C.lupus
phosphodiesterase 3B, cGMP-inhibited
1105 aa
   PDE3B,  B.taurus
phosphodiesterase 3B, cGMP-inhibited
1115 aa
   Pde3b,  M.musculus
phosphodiesterase 3B, cGMP-inhibited
1099 aa
   Pde3b,  R.norvegicus
phosphodiesterase 3B, cGMP-inhibited
1108 aa
   PDE3B,  G.gallus
phosphodiesterase 3B, cGMP-inhibited
1105 aa
   pde3b,  D.rerio
phosphodiesterase 3B, cGMP-inhibited
1103 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Differences in phosphodiesterase 3A and 3B expression after ischemic insult.
Mitome-Mishima Y, et al. Neurosci Res 75, 340-8 (2013).
From PDE3B to the regulation of energy homeostasis.
Degerman E, et al. Curr Opin Pharmacol 11, 676-82 (2011).
Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.
Walz HA, et al. Cell Signal 19, 1505-13 (2007).
Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B.
Lindh R, et al. Biochim Biophys Acta 1773, 584-92 (2007).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Spt5_N (pfam11942)
  Spt5 transcription elongation factor, acidic N-terminal.
ANAPC15 (pfam15243)
  Anaphase-promoting complex subunit 15.
DUF1129 (cl11555)
  Protein of unknown function (DUF1129).
Exosortase_EpsH (cl15694)
  Transmembrane exosortase (Exosortase_EpsH).
HDc (cl17215)
  Metal dependent phosphohydrolases with conserved 'HD' motif.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pde3b includes H.sapiens PDE3B and R.norvegicus Pde3b.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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