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HomoloGene:3192. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BCR,  H.sapiens
breakpoint cluster region
    NP_004318.3
1271 aa
   BCR,  P.troglodytes
breakpoint cluster region
    XP_003317181.1
1202 aa
   BCR,  M.mulatta
breakpoint cluster region
    XP_002798337.1
1148 aa
   BCR,  C.lupus
breakpoint cluster region
    XP_848654.2
1277 aa
   Bcr,  M.musculus
breakpoint cluster region
    NP_001074881.1
1270 aa
   Bcr,  R.norvegicus
breakpoint cluster region
    XP_228091.6
1270 aa
   BCR,  G.gallus
breakpoint cluster region
    XP_415244.3
1351 aa
   bcr,  X.tropicalis
breakpoint cluster region
    NP_001123792.1
1162 aa
   bcr,  D.rerio
breakpoint cluster region
    XP_005161278.1
1315 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, acute lymphocytic.
Leukemia, chronic myeloid.



Publications
Articles associated with genes and sequences of this homology group.

Tolerant anti-insulin B cells are effective APCs.
Kendall PL, et al. J Immunol 190, 2519-26 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Bcr-Abl_Oligo (pfam09036)
  Bcr-Abl oncoprotein oligomerisation domain.
PH-like (cl00273)
  Pleckstrin homology-like domain.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
C2 (cl14603)
  C2 domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.
HpaP (cl17849)
  Type III secretion protein (HpaP).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bcr includes H.sapiens BCR and R.norvegicus Bcr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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