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HomoloGene:37258. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CBS,  H.sapiens
cystathionine-beta-synthase
    NP_000062.1
551 aa
   LOC102724560,  H.sapiens
cystathionine beta-synthase-like
    XP_006723989.1
551 aa
   CBS,  P.troglodytes
cystathionine-beta-synthase
    XP_001143121.1
551 aa
   CBS,  C.lupus
cystathionine-beta-synthase
    XP_853796.2
567 aa
   CBS,  B.taurus
cystathionine-beta-synthase
    NP_001095470.1
571 aa
   Cbs,  M.musculus
cystathionine beta-synthase
    NP_001258282.1
547 aa
   Cbs,  R.norvegicus
cystathionine beta synthase
    NP_036654.2
547 aa
   CBS,  G.gallus
cystathionine-beta-synthase
    XP_416752.3
567 aa
   cbs,  X.tropicalis
cystathionine-beta-synthase
    NP_001008171.1
562 aa
   cbsa,  D.rerio
cystathionine-beta-synthase a
    NP_001104702.1
571 aa
   cbsb,  D.rerio
cystathionine-beta-synthase b
    NP_001014367.2
597 aa
   Cbs,  D.melanogaster
Cystathionine beta-synthase
    NP_728384.1
522 aa
   AgaP_AGAP000162,  A.gambiae
AgaP_AGAP000162
    XP_310977.5
537 aa
   CYS4,  S.cerevisiae
CYS4
    NP_011671.3
507 aa
   KLLA0F09317g,  K.lactis
KLLA0F09317g
    XP_455504.1
493 aa
   AGOS_AGR012C,  E.gossypii
AGOS_AGR012C
    NP_986677.2
492 aa
   MGG_07384,  M.oryzae
MGG_07384
    XP_003711260.1
533 aa
   NCU08216,  N.crassa
NCU08216
    XP_959306.1
528 aa
   Os06g0564700,  O.sativa
Os06g0564700
    NP_001057885.1
342 aa
   Os06g0149700,  O.sativa
Os06g0149700
    NP_001056819.1
339 aa
   Os06g0564500,  O.sativa
Os06g0564500
    NP_001057884.1
357 aa
   Os06g0149900,  O.sativa
Os06g0149900
    NP_001056820.1
347 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Homocystinuria, B6-responsive and nonresponsive types.
Thrombosis, hyperhomocysteinemic.



Publications
Articles associated with genes and sequences of this homology group.

Cystathionine beta synthase expression in mouse retina.
Markand S, et al. Curr Eye Res 38, 597-604 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trp-synth-beta_II (cl00342)
  Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
CBS_pair (cl15354)
  The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cbs includes H.sapiens CBS and R.norvegicus Cbs.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (24 transcripts, 11 species)
Mammalia - mammals (12 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 11 species)
Arachnida - arachnids (5 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (3 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (23 transcripts, 8 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Eudicotyledons - eudicots (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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