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HomoloGene:4764. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   NCOA3,  H.sapiens
nuclear receptor coactivator 3
1424 aa
   NCOA3,  P.troglodytes
nuclear receptor coactivator 3
1422 aa
   NCOA3,  M.mulatta
nuclear receptor coactivator 3
1425 aa
   NCOA3,  B.taurus
nuclear receptor coactivator 3
1411 aa
   Ncoa3,  M.musculus
nuclear receptor coactivator 3
1403 aa
   Ncoa3,  R.norvegicus
nuclear receptor coactivator 3
1400 aa
   NCOA3,  G.gallus
nuclear receptor coactivator 3
1404 aa
   ncoa3,  X.tropicalis
nuclear receptor coactivator 3
1342 aa
   ncoa3,  D.rerio
nuclear receptor coactivator 3
1497 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer.
Burandt E, et al. Breast Cancer Res Treat 137, 745-53 (2013).
Amplifications of NCOA3 gene in colorectal cancers in a Chinese population.
Li Z, et al. World J Gastroenterol 18, 855-60 (2012).
Expression of AIB1 protein as a prognostic factor in breast cancer.
Lee K, et al. World J Surg Oncol 9, 139 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Nuc_rec_co-act (pfam08815)
  Nuclear receptor coactivator.
DUF1518 (pfam07469)
  Domain of unknown function (DUF1518).
SRC-1 (pfam08832)
  Steroid receptor coactivator.
PAS (cd00130)
  PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
DUF1518 (pfam07469)
  Domain of unknown function (DUF1518).
SRC-1 (pfam08832)
  Steroid receptor coactivator.
PAS_11 (pfam14598)
  PAS domain.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ncoa3 includes H.sapiens NCOA3 and R.norvegicus Ncoa3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (15 transcripts, 9 species)
Actinopterygii - bony fishes (4 transcripts, 2 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)




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