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HomoloGene:2941. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SOCS3,  H.sapiens
suppressor of cytokine signaling 3
    NP_003946.3
225 aa
   SOCS3,  P.troglodytes
suppressor of cytokine signaling 3
    XP_001157032.1
225 aa
   SOCS3,  M.mulatta
suppressor of cytokine signaling 3
    XP_001106015.2
225 aa
   SOCS3,  C.lupus
suppressor of cytokine signaling 3
    NP_001026801.1
225 aa
   SOCS3,  B.taurus
suppressor of cytokine signaling 3
    NP_776891.1
229 aa
   Socs3,  M.musculus
suppressor of cytokine signaling 3
    NP_031733.1
225 aa
   Socs3,  R.norvegicus
suppressor of cytokine signaling 3
    NP_446017.1
225 aa
   SOCS3,  G.gallus
suppressor of cytokine signaling 3
    NP_989931.1
209 aa
   socs3,  X.tropicalis
suppressor of cytokine signaling 3
    NP_001005696.1
199 aa
   socs3b,  D.rerio
suppressor of cytokine signaling 3b
    NP_998469.1
210 aa
   socs3a,  D.rerio
suppressor of cytokine signaling 3a
    NP_956244.1
207 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dermatitis, atopic, 4.



Publications
Articles associated with genes and sequences of this homology group.

Gene methylation and silencing of SOCS3 in mantle cell lymphoma.
Molavi O, et al. Br J Haematol 161, 348-56 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SOCS (cl02533)
  SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
SOCS (cl02533)
  SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Socs3 includes H.sapiens SOCS3 and R.norvegicus Socs3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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