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HomoloGene:396. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HNF1B,  H.sapiens
HNF1 homeobox B
    NP_000449.1
557 aa
   HNF1B,  P.troglodytes
HNF1 homeobox B
    XP_523618.2
557 aa
   HNF1B,  M.mulatta
HNF1 homeobox B
    XP_001112223.1
557 aa
   LOC610402,  C.lupus
hepatocyte nuclear factor 1-beta-like
    XP_005624847.1
558 aa
   HNF1B,  B.taurus
HNF1 homeobox B
    NP_001179784.1
557 aa
   Hnf1b,  M.musculus
HNF1 homeobox B
    NP_033356.2
558 aa
   Hnf1b,  R.norvegicus
HNF1 homeobox B
    NP_037235.1
557 aa
   HNF1B,  G.gallus
HNF1 homeobox B
    XP_004946816.1
565 aa
   hnf1b,  X.tropicalis
HNF1 homeobox B
    XP_002939679.1
561 aa
   hnf1ba,  D.rerio
HNF1 homeobox Ba
    NP_571955.3
559 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, noninsulin-dependent.
Renal cysts and diabetes syndrome.



Publications
Articles associated with genes and sequences of this homology group.

HNF1β is essential for nephron segmentation during nephrogenesis.
Naylor RW, et al. J Am Soc Nephrol 24, 77-87 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HNF-1_N (pfam04814)
  Hepatocyte nuclear factor 1 (HNF-1), N terminus.
HNF-1B_C (pfam04812)
  Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus.
HNF-1B_C (pfam04812)
  Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus.
HNF-1_N (pfam04814)
  Hepatocyte nuclear factor 1 (HNF-1), N terminus.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hnf1b includes H.sapiens HNF1B and R.norvegicus Hnf1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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