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HomoloGene:3058. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MYO9B,  H.sapiens
myosin IXB
    NP_004136.2
2157 aa
   MYO9B,  P.troglodytes
myosin IXB
    XP_512476.3
2157 aa
   MYO9B,  M.mulatta
myosin IXB
    XP_001114282.2
2022 aa
   MYO9B,  C.lupus
myosin IXB
    XP_541960.2
2161 aa
   MYO9B,  B.taurus
myosin IXB
    NP_001180025.1
2159 aa
   Myo9b,  M.musculus
myosin IXb
    NP_001135794.1
2128 aa
   Myo9b,  R.norvegicus
myosin IXb
    NP_001257996.1
2011 aa
   MYO9B,  G.gallus
myosin IXB
    XP_418252.3
2039 aa
   myo9b,  X.tropicalis
myosin IXB
    XP_002934423.2
2153 aa
   myo9b,  D.rerio
myosin IXb
    XP_005171392.1
1915 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Celiac disease, susceptibility to, 4.



Publications
Articles associated with genes and sequences of this homology group.

Frequency of MYO9B polymorphisms in celiac patients and controls.
Loeff T, et al. Rev Esp Enferm Dig 104, 566-71 (2012).
Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.
Hanley PJ, et al. Proc Natl Acad Sci U S A 107, 12145-50 (2010).
Association analysis of myosin IXB and type 1 diabetes.
Persengiev S, et al. Hum Immunol 71, 598-601 (2010).
MYO9B polymorphisms in multiple sclerosis.
Kemppinen A, et al. Eur J Hum Genet 17, 840-3 (2009).
Association of MYO9B haplotype with type 1 diabetes.
Santiago JL, et al. Hum Immunol 69, 112-5 (2008).
Is MYO9B the missing link between schizophrenia and celiac disease?
Jungerius BJ, et al. Am J Med Genet B Neuropsychiatr Genet 147, 351-5 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PRK13863 (PRK13863)
  type IV secretion system T-DNA border endonuclease VirD2; Provisional.
UBQ (cl00155)
  Ubiquitin-like proteins.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
SARG (pfam15385)
  Specifically androgen-regulated gene protein.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
UBQ (cl00155)
  Ubiquitin-like proteins.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
IQ (cl15479)
  Calmodulin-binding motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myo9b includes H.sapiens MYO9B and R.norvegicus Myo9b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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