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HomoloGene:22524. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   UCP1,  H.sapiens
uncoupling protein 1 (mitochondrial, proton carrier)
    NP_068605.1
307 aa
   UCP1,  P.troglodytes
uncoupling protein 1 (mitochondrial, proton carrier)
    XP_517450.3
373 aa
   UCP1,  M.mulatta
uncoupling protein 1 (mitochondrial, proton carrier)
    XP_001090457.1
307 aa
   UCP1,  C.lupus
uncoupling protein 1 (mitochondrial, proton carrier)
    NP_001003046.1
309 aa
   UCP1,  B.taurus
uncoupling protein 1 (mitochondrial, proton carrier)
    NP_001160000.1
309 aa
   Ucp1,  M.musculus
uncoupling protein 1 (mitochondrial, proton carrier)
    NP_033489.1
307 aa
   Ucp1,  R.norvegicus
uncoupling protein 1 (mitochondrial, proton carrier)
    NP_036814.1
307 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obesity, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Adult epicardial fat exhibits beige features.
Sacks HS, et al. J Clin Endocrinol Metab 98, E1448-55 (2013).
Fatty acids change the conformation of uncoupling protein 1 (UCP1).
Divakaruni AS, et al. J Biol Chem 287, 36845-53 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Mito_carr (pfam00153)
  Mitochondrial carrier protein.
Mito_carr (pfam00153)
  Mitochondrial carrier protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ucp1 includes H.sapiens UCP1 and R.norvegicus Ucp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)

 

 

 

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