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HomoloGene:49589. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TNXB,  H.sapiens
tenascin XB
    NP_061978.6
4242 aa
   TNXB,  P.troglodytes
tenascin-X-like
    XP_003311236.1
4242 aa
   LOC716998,  M.mulatta
tenascin-X-like
    XP_002808426.1
4243 aa
   TNXB,  C.lupus
tenascin XB
    XP_003431728.2
3966 aa
   TNXB,  B.taurus
tenascin XB
    NP_777128.1
4135 aa
   Tnxb,  M.musculus
tenascin XB
    NP_112453.2
3126 aa
   tnxb,  X.tropicalis
tenascin XB
    XP_002941313.2
2840 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ehlers-Danlos syndrome, hypermobility type.
Ehlers-Danlos due to tenascin X deficiency.



Publications
Articles associated with genes and sequences of this homology group.

TNXB mutations can cause vesicoureteral reflux.
Gbadegesin RA, et al. J Am Soc Nephrol 24, 1313-22 (2013).
Noticeable decreased expression of tenascin-X in calcific aortic valves.
Matsumoto K, et al. Connect Tissue Res 53, 460-8 (2012).
Tenascin-X is a novel diagnostic marker of malignant mesothelioma.
Yuan Y, et al. Am J Surg Pathol 33, 1673-82 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EGF_2 (pfam07974)
  EGF-like domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Stig1 (pfam04885)
  Stigma-specific protein, Stig1.
EGF_2 (pfam07974)
  EGF-like domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
FReD (cl00085)
  Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tnxb includes H.sapiens TNXB.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 6 species)

 

 

 

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