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HomoloGene:1533. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FN1,  H.sapiens
fibronectin 1
    NP_997647.1
2477 aa
   FN1,  P.troglodytes
fibronectin 1
    XP_516072.3
2477 aa
   FN1,  M.mulatta
fibronectin 1
    XP_001083548.2
2477 aa
   FN1,  C.lupus
fibronectin 1
    XP_005640798.1
2435 aa
   Fn1,  M.musculus
fibronectin 1
    NP_034363.1
2477 aa
   Fn1,  R.norvegicus
fibronectin 1
    NP_062016.2
2477 aa
   FN1,  G.gallus
fibronectin 1
    NP_001185641.1
2483 aa
   fn1,  X.tropicalis
fibronectin 1
    NP_001025695.1
2475 aa
   fn1a,  D.rerio
fibronectin 1a
    NP_571595.1
2478 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Glomerulopathy with fibronectin deposits 2.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
fn3 (pfam00041)
  Fibronectin type III domain.
FN1 (cl00063)
  Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
FN2 (cl09951)
  Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fn1 includes H.sapiens FN1 and R.norvegicus Fn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 8 species)
Aves - birds (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

 

 

 

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