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HomoloGene:313. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TPMT,  H.sapiens
thiopurine S-methyltransferase
    NP_000358.1
245 aa
   TPMT,  P.troglodytes
thiopurine S-methyltransferase
    NP_001030596.1
245 aa
   TPMT,  M.mulatta
thiopurine S-methyltransferase
    XP_001097433.1
245 aa
   TPMT,  C.lupus
thiopurine S-methyltransferase
    NP_001003015.1
245 aa
   TPMT,  B.taurus
thiopurine S-methyltransferase
    NP_001068999.1
245 aa
   Tpmt,  M.musculus
thiopurine methyltransferase
    NP_058065.2
240 aa
   Tpmt,  R.norvegicus
thiopurine S-methyltransferase
    NP_001072999.1
259 aa
   TPMT,  G.gallus
thiopurine S-methyltransferase
    XP_418921.1
239 aa
   tpmt,  X.tropicalis
thiopurine S-methyltransferase
    NP_001016410.1
225 aa
   zgc:101684,  D.rerio
zgc:101684
    NP_001028758.1
246 aa
   zgc:109981,  D.rerio
zgc:109981
    NP_001002569.2
231 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
6-mercaptopurine sensitivity.



Publications
Articles associated with genes and sequences of this homology group.

High-resolution melting analysis of the TPMT gene: a study in the Polish population.
Skrzypczak-Zielinska M, et al. Genet Test Mol Biomarkers 17, 153-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TPMT (pfam05724)
  Thiopurine S-methyltransferase (TPMT).
AdoMet_MTases (cl17173)
  S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tpmt includes H.sapiens TPMT and R.norvegicus Tpmt.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (4 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Arthropoda
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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