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HomoloGene:2426. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TFF1,  H.sapiens
trefoil factor 1
84 aa
   TFF1,  P.troglodytes
trefoil factor 1
84 aa
   LOC100423966,  M.mulatta
trefoil factor 1-like
160 aa
   TFF1,  C.lupus
trefoil factor 1
81 aa
   Tff1,  M.musculus
trefoil factor 1
87 aa
   Tff1,  R.norvegicus
trefoil factor 1
81 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Novel mutation causing Hermansky-Pudlak Syndrome Type 2.
Chiang PW, et al. Pediatr Blood Cancer 55, 1438 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trefoil (cl00103)
  P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tff1 includes H.sapiens TFF1 and R.norvegicus Tff1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)




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