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HomoloGene:47908. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FXN,  H.sapiens
frataxin
    NP_000135.2
210 aa
   FXN,  P.troglodytes
frataxin
    XP_001137864.2
238 aa
   FXN,  M.mulatta
frataxin
    XP_001093449.1
210 aa
   FXN,  C.lupus
frataxin
    NP_001103428.1
211 aa
   FXN,  B.taurus
frataxin
    NP_001074196.1
217 aa
   Fxn,  M.musculus
frataxin
    NP_032070.1
207 aa
   Fxn,  R.norvegicus
frataxin
    NP_001178881.1
206 aa
   FXN,  G.gallus
frataxin
    XP_424827.3
197 aa
   LOC100497789,  X.tropicalis
frataxin, mitochondrial-like
    XP_004910856.1
161 aa
   fxn,  D.rerio
frataxin
    NP_001076485.1
169 aa
   FH,  A.thaliana
FH
    NP_192233.2
187 aa
   Os01g0783600,  O.sativa
Os01g0783600
    NP_001044455.2
84 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Friedreich ataxia.
Friedreich ataxia with retained reflexes.



Publications
Articles associated with genes and sequences of this homology group.

Frataxin: a protein in search for a function.
Pastore A & Puccio H. J Neurochem 126 Suppl 1, 43-52 (2013).
Friedreich ataxia: neuropathology revised.
Koeppen AH & Mazurkiewicz JE. J Neuropathol Exp Neurol 72, 78-90 (2013).
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia.
Whitnall M, et al. Proc Natl Acad Sci U S A 109, 20590-5 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Frataxin (cl00238)
  Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fxn includes H.sapiens FXN and R.norvegicus Fxn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (21 transcripts, 19 species)
Liliopsida - monocots (7 transcripts, 5 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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