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HomoloGene:68069. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RYR1,  H.sapiens
ryanodine receptor 1 (skeletal)
    NP_000531.2
5038 aa
   RYR1,  P.troglodytes
ryanodine receptor 1 (skeletal)
    XP_003316361.1
5037 aa
   RYR1,  C.lupus
ryanodine receptor 1 (skeletal)
    XP_003638883.1
5038 aa
   RYR1,  B.taurus
ryanodine receptor 1 (skeletal)
    NP_001193706.1
5040 aa
   Ryr1,  M.musculus
ryanodine receptor 1, skeletal muscle
    NP_033135.2
5035 aa
   Ryr1,  R.norvegicus
ryanodine receptor 1 (skeletal)
    XP_006228792.1
4285 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Central core disease.
Malignant hyperthermia susceptibility 1.



Publications
Articles associated with genes and sequences of this homology group.

Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis.
Dlamini N, et al. Neuromuscul Disord 23, 540-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RyR (pfam02026)
  RyR domain.
Ion_trans (pfam00520)
  Ion transport protein.
RYDR_ITPR (pfam01365)
  RIH domain.
RR_TM4-6 (pfam06459)
  Ryanodine Receptor TM 4-6.
RIH_assoc (pfam08454)
  RyR and IP3R Homology associated.
EF_hand_6 (pfam13833)
  EF-hand domain pair.
Ion_trans (pfam00520)
  Ion transport protein.
RYDR_ITPR (pfam01365)
  RIH domain.
RyR (pfam02026)
  RyR domain.
RR_TM4-6 (pfam06459)
  Ryanodine Receptor TM 4-6.
RIH_assoc (pfam08454)
  RyR and IP3R Homology associated.
SPRY (cl02614)
  SPRY domain.
EF-hand_8 (cl17302)
  EF-hand domain pair.
Ins145_P3_rec (cl19745)
  Inositol 1,4,5-trisphosphate/ryanodine receptor.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ryr1 includes H.sapiens RYR1 and R.norvegicus LOC686059.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (38 transcripts, 9 species)
Mammalia - mammals (36 transcripts, 11 species)
Amniota - vertebrates (4 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

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