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HomoloGene:503. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   HGF,  H.sapiens
hepatocyte growth factor (hepapoietin A; scatter factor)
728 aa
   HGF,  P.troglodytes
hepatocyte growth factor (hepapoietin A; scatter factor)
728 aa
   HGF,  M.mulatta
hepatocyte growth factor (hepapoietin A; scatter factor)
788 aa
   HGF,  C.lupus
hepatocyte growth factor (hepapoietin A; scatter factor)
730 aa
   HGF,  B.taurus
hepatocyte growth factor (hepapoietin A; scatter factor)
730 aa
   Hgf,  M.musculus
hepatocyte growth factor
728 aa
   Hgf,  R.norvegicus
hepatocyte growth factor
728 aa
   HGF,  G.gallus
hepatocyte growth factor (hepapoietin A; scatter factor)
726 aa
   hgf,  X.tropicalis
hepatocyte growth factor (hepapoietin A; scatter factor)
710 aa
   hgfa,  D.rerio
hepatocyte growth factor a
699 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Deafness, autosomal recessive 39.

Articles associated with genes and sequences of this homology group.

Hepatocyte growth factor regulates neovascularization in developing fat pads.
White HM, et al. Am J Physiol Endocrinol Metab 306, E189-96 (2014).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (smart00020)
  Trypsin-like serine protease.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
KR (cl00100)
  Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
PAN_APPLE (cl00112)
  PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hgf includes H.sapiens HGF and R.norvegicus Hgf.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 11 species)
Cephalochordata - lancelets (4 transcripts, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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