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HomoloGene:1334. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CCND1,  H.sapiens
cyclin D1
    NP_444284.1
295 aa
   CCND1,  P.troglodytes
cyclin D1
    XP_003952008.1
564 aa
   CCND1,  M.mulatta
G1/S-specific cyclin-D1
    XP_001101029.1
295 aa
   CCND1,  C.lupus
cyclin D1
    NP_001005757.1
295 aa
   CCND1,  B.taurus
cyclin D1
    NP_001039738.1
295 aa
   Ccnd1,  M.musculus
cyclin D1
    NP_031657.1
295 aa
   Ccnd1,  R.norvegicus
cyclin D1
    NP_741989.3
295 aa
   CCND1,  G.gallus
cyclin D1
    NP_990712.1
292 aa
   ccnd1,  X.tropicalis
cyclin D1
    NP_001005452.1
291 aa
   ccnd1,  D.rerio
cyclin D1
    NP_571100.1
291 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia/lymphoma, chronic B-cell.
Centrocytic lymphoma.
Colorectal cancer, susceptibility to.
Parathyroid adenomatosis 1.
von Hippel-Lindau disease, modification of.
Multiple myeloma.



Publications
Articles associated with genes and sequences of this homology group.

Cyclin D1 gene G870A variants and primary brain tumors.
Zeybek U, et al. Asian Pac J Cancer Prev 14, 4101-6 (2013).
Female-specific rectal carcinogenesis in cyclin D1b transgenic mice.
Kim CJ, et al. Carcinogenesis 35, 227-36 (2014).
Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing.
Pyo CW, et al. Biochim Biophys Acta 1830, 5316-25 (2013).
Relationship between cyclin D1 (A870G) gene polymorphism and lung cancer.
Cakina S, et al. Indian J Biochem Biophys 50, 233-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cyclin_C (pfam02984)
  Cyclin, C-terminal domain.
CYCLIN (cl00050)
  Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ccnd1 includes H.sapiens CCND1 and R.norvegicus Ccnd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (16 transcripts, 10 species)
Mammalia - mammals (13 transcripts, 11 species)
Amphibia - amphibians (7 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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