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HomoloGene:17060. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HFE2,  H.sapiens
hemochromatosis type 2 (juvenile)
    NP_998818.1
426 aa
   HFE2,  P.troglodytes
hemochromatosis type 2 (juvenile)
    XP_001163074.1
200 aa
   HFE2,  M.mulatta
hemochromatosis type 2 (juvenile)
    XP_001092987.1
427 aa
   HFE2,  C.lupus
hemochromatosis type 2 (juvenile)
    XP_859524.3
426 aa
   HFE2,  B.taurus
hemochromatosis type 2 (juvenile)
    NP_001193843.1
427 aa
   Hfe2,  M.musculus
hemochromatosis type 2 (juvenile) (human homolog)
    NP_081402.3
420 aa
   Hfe2,  R.norvegicus
hemochromatosis type 2 (juvenile)
    NP_001012080.1
422 aa
   hfe2,  X.tropicalis
hemochromatosis type 2 (juvenile)
    XP_002938521.2
402 aa
   hfe2,  D.rerio
hemochromatosis type 2
    XP_005158349.1
410 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hemochromatosis, type 2A.



Publications
Articles associated with genes and sequences of this homology group.

Iron-mediated retinal degeneration in haemojuvelin-knockout mice.
Gnana-Prakasam JP, et al. Biochem J 441, 599-608 (2012).
Liver and muscle hemojuvelin are differently glycosylated.
Fujikura Y, et al. BMC Biochem 12, 52 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RGM_C (pfam06534)
  Repulsive guidance molecule (RGM) C-terminus.
RGM_N (pfam06535)
  Repulsive guidance molecule (RGM) N-terminus.
RGM_C (pfam06534)
  Repulsive guidance molecule (RGM) C-terminus.
RGM_N (pfam06535)
  Repulsive guidance molecule (RGM) N-terminus.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hfe2 includes H.sapiens HFE2 and R.norvegicus Hfe2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)

 

 

 

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