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HomoloGene:9266. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LPIN1,  H.sapiens
lipin 1
    NP_001248357.1
975 aa
   LPIN1,  P.troglodytes
lipin 1
    XP_001160223.2
975 aa
   LOC697682,  M.mulatta
phosphatidate phosphatase LPIN1-like
    XP_002808075.1
956 aa
   LPIN1,  C.lupus
lipin 1
    XP_532878.3
977 aa
   LPIN1,  B.taurus
lipin 1
    NP_001193085.1
895 aa
   Lpin1,  M.musculus
lipin 1
    NP_056578.2
924 aa
   Lpin1,  R.norvegicus
lipin 1
    NP_001012111.1
924 aa
   LPIN1,  G.gallus
lipin 1
    XP_004935828.1
987 aa
   lpin1,  X.tropicalis
lipin 1
    NP_001072495.1
842 aa
   lpin1,  D.rerio
lipin 1
    NP_001037818.1
894 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myoglobinuria, acute recurrent, autosomal recessive.



Publications
Articles associated with genes and sequences of this homology group.

Lipin1 regulates PPARĪ³ transcriptional activity.
Kim HE, et al. Biochem J 453, 49-60 (2013).
Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes.
Takahashi N, et al. Biochem Biophys Res Commun 431, 25-30 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LNS2 (pfam08235)
  LNS2 (Lipin/Ned1/Smp2).
Lipin_N (pfam04571)
  lipin, N-terminal conserved region.
Lipin_N (pfam04571)
  lipin, N-terminal conserved region.
AF1Q (pfam15017)
  Drug resistance and apoptosis regulator.
LNS2 (cl19358)
  LNS2 (Lipin/Ned1/Smp2).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lpin1 includes H.sapiens LPIN1 and R.norvegicus Lpin1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (13 transcripts, 7 species)
Mammalia - mammals (10 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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