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HomoloGene:3797. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   COMMD3-BMI1,  H.sapiens
COMMD3-BMI1 readthrough
469 aa
   COMMD3,  M.mulatta
COMM domain containing 3
469 aa
   BMI1,  C.lupus
BMI1 polycomb ring finger oncogene
326 aa
   BMI1,  B.taurus
BMI1 polycomb ring finger oncogene
326 aa
   Bmi1,  M.musculus
Bmi1 polycomb ring finger oncogene
324 aa
   Bmi1,  R.norvegicus
Bmi1 polycomb ring finger oncogene
324 aa
   BMI1,  G.gallus
BMI1 polycomb ring finger oncogene
326 aa
   bmi1,  X.tropicalis
BMI1 polycomb ring finger oncogene
325 aa
   bmi1b,  D.rerio
B lymphoma Mo-MLV insertion region 1b
324 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Bmi1 is required for regeneration of the exocrine pancreas in mice.
Fukuda A, et al. Gastroenterology 143, 821-31.e1-2 (2012).
Bmi-1 absence causes premature brain degeneration.
Cao G, et al. PLoS One 7, e32015 (2012).
An anticlastogenic function for the Polycomb Group gene Bmi1.
Chagraoui J, et al. Proc Natl Acad Sci U S A 108, 5284-9 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
Commd (cl06336)
  COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bmi1 includes H.sapiens BMI1 and R.norvegicus Bmi1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Insecta - insects (3 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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