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HomoloGene:11280. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IREB2,  H.sapiens
iron-responsive element binding protein 2
    NP_004127.1
963 aa
   IREB2,  P.troglodytes
iron-responsive element binding protein 2
    XP_523125.2
963 aa
   IREB2,  M.mulatta
iron-responsive element binding protein 2
    XP_001107837.1
964 aa
   IREB2,  C.lupus
iron-responsive element binding protein 2
    XP_532364.2
964 aa
   IREB2,  B.taurus
iron-responsive element binding protein 2
    XP_002696712.2
928 aa
   Ireb2,  M.musculus
iron responsive element binding protein 2
    NP_073146.2
963 aa
   Ireb2,  R.norvegicus
iron responsive element binding protein 2
    NP_074054.2
963 aa
   IREB2,  G.gallus
iron-responsive element binding protein 2
    NP_001026625.1
965 aa
   ireb2,  X.tropicalis
iron-responsive element binding protein 2
    NP_001072764.1
957 aa
   ireb2,  D.rerio
iron-responsive element binding protein 2
    XP_005163029.1
974 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

IRP2 regulates breast tumor growth.
Wang W, et al. Cancer Res 74, 497-507 (2014).
[Regulating action of iron regulatory protein-2 in iron metabolism of lung cancer].
Cheng Z, et al. Zhonghua Yi Xue Za Zhi 91, 1992-5 (2011).
Iron regulatory protein 2 turnover through a nonproteasomal pathway.
Chang AH, et al. J Biol Chem 286, 23698-707 (2011).
Redox control of iron regulatory protein 2 stability.
Hausmann A, et al. FEBS Lett 585, 687-92 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Aconitase (cl00285)
  Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.
Aconitase_swivel (cl00215)
  Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme ...
Aconitase (cl00285)
  Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ireb2 includes H.sapiens IREB2 and R.norvegicus Ireb2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (13 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (4 transcripts, 1 species)

 

 

 

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