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HomoloGene:37288. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PROC,  H.sapiens
protein C (inactivator of coagulation factors Va and VIIIa)
    NP_000303.1
461 aa
   PROC,  P.troglodytes
protein C (inactivator of coagulation factors Va and VIIIa)
    XP_515775.3
461 aa
   PROC,  M.mulatta
protein C (inactivator of coagulation factors Va and VIIIa)
    XP_001087196.2
523 aa
   LOC476104,  C.lupus
vitamin K-dependent protein C-like
    NP_001013871.1
456 aa
   PROC,  B.taurus
protein C (inactivator of coagulation factors Va and VIIIa)
    NP_001159984.1
480 aa
   Proc,  M.musculus
protein C
    NP_032960.3
481 aa
   Proc,  R.norvegicus
protein C
    NP_036935.1
461 aa
   PROC,  G.gallus
protein C (inactivator of coagulation factors Va and VIIIa)
    NP_989772.1
433 aa
   proc,  X.tropicalis
protein C (inactivator of coagulation factors Va and VIIIa)
    NP_001015759.1
456 aa
   proca,  D.rerio
protein C (inactivator of coagulation factors Va and VIIIa), a
    NP_956650.1
434 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Purpura fulminans, neonatal.
Thrombophilia due to protein C deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Genetic variants associated with protein C levels.
Vossen CY, et al. J Thromb Haemost 11, 715-23 (2013).
Protein C polymorphism and susceptibility to PTE in China.
Zhang YJ, et al. Blood Coagul Fibrinolysis 23, 693-9 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Gla (cl02449)
  Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Proc includes H.sapiens PROC and R.norvegicus Proc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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