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HomoloGene:839. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ZAP70,  H.sapiens
zeta-chain (TCR) associated protein kinase 70kDa
    NP_001070.2
619 aa
   ZAP70,  P.troglodytes
zeta-chain (TCR) associated protein kinase 70kDa
    XP_515637.2
619 aa
   ZAP70,  M.mulatta
zeta-chain (TCR) associated protein kinase 70kDa
    XP_001101570.2
746 aa
   ZAP70,  C.lupus
zeta-chain (TCR) associated protein kinase 70kDa
    XP_005626103.1
629 aa
   ZAP70,  B.taurus
zeta-chain (TCR) associated protein kinase 70kDa
    NP_001179946.1
617 aa
   Zap70,  M.musculus
zeta-chain (TCR) associated protein kinase
    NP_033565.2
618 aa
   Zap70,  R.norvegicus
zeta-chain (TCR) associated protein kinase 70
    NP_001012002.1
614 aa
   ZAP70,  G.gallus
zeta-chain (TCR) associated protein kinase 70kDa
    XP_418206.4
609 aa
   zap70,  X.tropicalis
zeta-chain (TCR) associated protein kinase 70kDa
    NP_001006825.1
609 aa
   zap70,  D.rerio
zeta-chain (TCR) associated protein kinase
    NP_001018425.1
604 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Selective T-cell defect.



Publications
Articles associated with genes and sequences of this homology group.

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system.
Sinclair C, et al. Proc Natl Acad Sci U S A 110, E2905-14 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Zap70 includes H.sapiens ZAP70 and R.norvegicus Zap70.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (10 transcripts, 7 species)
Mammalia - mammals (8 transcripts, 8 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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