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HomoloGene:88621. Gene conserved in Euarchontoglires Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   UGT1A4,  H.sapiens
UDP glucuronosyltransferase 1 family, polypeptide A4
534 aa
   Ugt1a5,  M.musculus
UDP glucuronosyltransferase 1 family, polypeptide A5
529 aa
   Ugt1a5,  R.norvegicus
UDP glucuronosyltransferase 1 family, polypeptide A5
531 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes.
Zhou J, et al. Pharmacogenomics 12, 1671-9 (2011).
A pharmacogenetics study of the human glucuronosyltransferase UGT1A4.
Benoit-Biancamano MO, et al. Pharmacogenet Genomics 19, 945-54 (2009).
Pediatric development of glucuronidation: the ontogeny of hepatic UGT1A4.
Miyagi SJ & Collier AC. Drug Metab Dispos 35, 1587-92 (2007).
Genetic variations and haplotypes of UGT1A4 in a Japanese population.
Saeki M, et al. Drug Metab Pharmacokinet 20, 144-51 (2005).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
UDPGT (pfam00201)
  UDP-glucoronosyl and UDP-glucosyl transferase.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ugt1a5 includes H.sapiens UGT1A5 and R.norvegicus Ugt1a5.




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