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HomoloGene:1593. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HTT,  H.sapiens
huntingtin
    NP_002102.4
3144 aa
   HTT,  P.troglodytes
huntingtin
    XP_517080.4
3343 aa
   HTT,  C.lupus
huntingtin
    XP_536221.2
3130 aa
   HTT,  B.taurus
huntingtin
    XP_002688476.1
3131 aa
   Htt,  M.musculus
huntingtin
    NP_034544.1
3120 aa
   Htt,  R.norvegicus
huntingtin
    NP_077333.2
3120 aa
   HTT,  G.gallus
huntingtin
    XP_420822.3
3095 aa
   htt,  X.tropicalis
huntingtin
    NP_001007904.1
1148 aa
   htt,  D.rerio
huntingtin
    NP_571093.1
3121 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Huntington disease.



Publications
Articles associated with genes and sequences of this homology group.

Clinical and genetic features of Huntington disease in Sri Lanka.
Sumathipala DS, et al. BMC Neurol 13, 191 (2013).
MeCP2: a novel Huntingtin interactor.
McFarland KN, et al. Hum Mol Genet 23, 1036-44 (2014).
HTRF analysis of soluble huntingtin in PHAROS PBMCs.
Moscovitch-Lopatin M, et al. Neurology 81, 1134-40 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3652 (pfam12372)
  Huntingtin protein region.
SWI-SNF_Ssr4 (pfam08549)
  Fungal domain of unknown function (DUF1750).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Htt includes H.sapiens HTT and R.norvegicus Htt.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 6 species)
Mammalia - mammals (10 transcripts, 9 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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