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HomoloGene:3996. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GNE,  H.sapiens
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    NP_001121699.1
753 aa
   GNE,  P.troglodytes
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    XP_003312121.1
753 aa
   GNE,  M.mulatta
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    XP_001082113.2
722 aa
   GNE,  C.lupus
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    XP_003431623.1
752 aa
   GNE,  B.taurus
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    NP_001178072.2
722 aa
   Gne,  M.musculus
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    NP_056643.3
753 aa
   Gne,  R.norvegicus
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    NP_446217.1
722 aa
   GNE,  G.gallus
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    NP_001026603.2
754 aa
   gne,  X.tropicalis
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    NP_001072728.1
722 aa
   gne,  D.rerio
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
    NP_957177.1
725 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Sialuria.
Inclusion body myopathy, autosomal recessive.
Nonaka myopathy.



Publications
Articles associated with genes and sequences of this homology group.

GNE myopathy in India.
Nalini A, et al. Neurol India 61, 371-4 (2013).
Variable phenotypes of knockin mice carrying the M712T Gne mutation.
Sela I, et al. Neuromolecular Med 15, 180-91 (2013).
Muscle imaging findings in GNE myopathy.
Tasca G, et al. J Neurol 259, 1358-65 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NeuC_NnaA (TIGR03568)
  UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing.
NBD_sugar-kinase_HSP70_actin (cl17037)
  Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gne includes H.sapiens GNE and R.norvegicus Gne.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 9 species)
Mammalia - mammals (14 transcripts, 10 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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