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HomoloGene:13251. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DICER1,  H.sapiens
dicer 1, ribonuclease type III
    NP_085124.2
1922 aa
   DICER1,  P.troglodytes
dicer 1, ribonuclease type III
    XP_001154369.1
1922 aa
   DICER1,  M.mulatta
dicer 1, ribonuclease type III
    XP_001100868.1
1920 aa
   DICER1,  C.lupus
dicer 1, ribonuclease type III
    XP_868526.3
1924 aa
   DICER1,  B.taurus
dicer 1, ribonuclease type III
    NP_976235.1
1923 aa
   Dicer1,  M.musculus
dicer 1, ribonuclease type III
    NP_683750.2
1906 aa
   Dicer1,  R.norvegicus
dicer 1, ribonuclease type III
    XP_006240573.1
1919 aa
   DICER1,  G.gallus
dicer 1, ribonuclease type III
    NP_001035555.1
1921 aa
   dicer1,  X.tropicalis
dicer 1, ribonuclease type III
    NP_001123390.2
1893 aa
   dicer1,  D.rerio
Dicer1, Dcr-1 homolog (Drosophila)
    NP_001154925.1
1865 aa
   Dcr-1,  D.melanogaster
Dicer-1
    NP_524453.1
2249 aa
   AgaP_AGAP002836,  A.gambiae
AgaP_AGAP002836
    XP_003436256.1
2336 aa
   dcr-1,  C.elegans
dcr-1
    NP_498761.2
1910 aa
   dcr1,  S.pombe
dcr1
    NP_588215.2
1374 aa
   MGG_01541,  M.oryzae
MGG_01541
    XP_003714515.1
1591 aa
   NCU08270,  N.crassa
NCU08270
    XP_961898.1
1584 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pleuropulmonary blastoma.



Publications
Articles associated with genes and sequences of this homology group.

DICER1 hotspot mutations in non-epithelial gonadal tumours.
Witkowski L, et al. Br J Cancer 109, 2744-50 (2013).
Germ-line and somatic DICER1 mutations in a pleuropulmonary blastoma.
de Kock L, et al. Pediatr Blood Cancer 60, 2091-2 (2013).
Conserved microRNA pathway regulates developmental timing of retinal neurogenesis.
La Torre A, et al. Proc Natl Acad Sci U S A 110, E2362-70 (2013).
DICER1 syndrome: a new cancer syndrome.
Schultze-Florey RE, et al. Klin Padiatr 225, 177-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
dsRNA_bind (pfam03368)
  Double stranded RNA binding domain.
DEXDc (smart00487)
  DEAD-like helicases superfamily.
Rnc (COG0571)
  dsRNA-specific ribonuclease [Transcription].
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
Dicer_dimer (pfam03368)
  Dicer dimerization domain.
DSRM (cl00054)
  Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
RIBOc (cl00258)
  RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
PAZ (cl00301)
  PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a ...
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Tape_meas_lam_C (cl19901)
  Lambda phage tail tape-measure protein (Tape_meas_lam_C).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dicer1 includes H.sapiens DICER1 and R.norvegicus Dicer1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (13 transcripts, 6 species)
Ascidiacea - tunicates (6 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (4 transcripts, 2 species)
Insecta - insects (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (10 transcripts, 10 species)
Liliopsida - monocots (3 transcripts, 3 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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