Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:110. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FAH,  H.sapiens
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    NP_000128.1
419 aa
   FAH,  P.troglodytes
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    XP_001155533.3
421 aa
   FAH,  M.mulatta
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    XP_001109382.1
419 aa
   FAH,  C.lupus
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    XP_005618474.1
419 aa
   FAH,  B.taurus
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    NP_001092382.1
419 aa
   Fah,  M.musculus
fumarylacetoacetate hydrolase
    NP_034306.2
419 aa
   Fah,  R.norvegicus
fumarylacetoacetate hydrolase
    NP_058877.1
419 aa
   FAH,  G.gallus
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    NP_001264402.1
419 aa
   fah,  X.tropicalis
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    NP_001107523.1
420 aa
   fah,  D.rerio
fumarylacetoacetate hydrolase (fumarylacetoacetase)
    NP_955895.1
348 aa
   Faa,  D.melanogaster
Fumarylacetoacetase
    NP_524830.2
417 aa
   AgaP_AGAP005865,  A.gambiae
AgaP_AGAP005865
    XP_315893.3
416 aa
   fah-1,  C.elegans
fah-1
    NP_509083.1
418 aa
   MGG_00317,  M.oryzae
MGG_00317
    XP_003718771.1
437 aa
   NCU05537,  N.crassa
NCU05537
    XP_960499.1
429 aa
   AT1G12050,  A.thaliana
AT1G12050
    NP_172669.2
421 aa
   Os02g0196800,  O.sativa
Os02g0196800
    NP_001046195.1
429 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Tyrosinemia, type I.



Publications
Articles associated with genes and sequences of this homology group.

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice.
Vaughan AM, et al. J Clin Invest 122, 3618-28 (2012).
High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice.
Eggenhofer E, et al. J Gastroenterol Hepatol 25, 1002-8 (2010).
Tyrosinemia Type I
Sniderman King L, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FAA_hydrolase (pfam01557)
  Fumarylacetoacetate (FAA) hydrolase family.
DUF1969 (pfam09298)
  Domain of unknown function (DUF1969).
FAA_hydrolase_N (pfam09298)
  Fumarylacetoacetase N-terminal.
FAA_hydrolase (cl11421)
  Fumarylacetoacetate (FAA) hydrolase family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fah includes H.sapiens FAH and R.norvegicus Fah.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (44 transcripts, 34 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

Write to the Help Desk