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HomoloGene:21001. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MMP20,  H.sapiens
matrix metallopeptidase 20
    NP_004762.2
483 aa
   MMP20,  P.troglodytes
matrix metallopeptidase 20
    XP_001153208.1
483 aa
   MMP20,  M.mulatta
matrix metallopeptidase 20
    XP_001097602.1
483 aa
   MMP20,  C.lupus
matrix metallopeptidase 20
    XP_854639.1
483 aa
   MMP20,  B.taurus
matrix metallopeptidase 20
    NP_776816.1
481 aa
   Mmp20,  M.musculus
matrix metallopeptidase 20 (enamelysin)
    NP_038931.1
482 aa
   Mmp20,  R.norvegicus
matrix metallopeptidase 20
    NP_001100270.1
482 aa
   mmp20,  X.tropicalis
matrix metallopeptidase 20
    XP_002934967.2
458 aa
   LOC100329766,  D.rerio
matrix metalloproteinase-20-like
    XP_002664668.3
465 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amelogenesis imperfecta, pigmented hypomaturation type.



Publications
Articles associated with genes and sequences of this homology group.

MMP20 modulates cadherin expression in ameloblasts as enamel develops.
Guan X & Bartlett JD. J Dent Res 92, 1123-8 (2013).
Formation of the dentino-enamel interface in enamelysin (MMP-20)-deficient mouse incisors.
Beniash E, et al. Eur J Oral Sci 114 Suppl 1, 24-9; discussion 39-41, 379 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
HX (cd00094)
  Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mmp20 includes H.sapiens MMP20 and R.norvegicus Mmp20.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)

 

 

 

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