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HomoloGene:90883. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DNM2,  H.sapiens
dynamin 2
    NP_001005361.1
870 aa
   DNM2,  P.troglodytes
dynamin 2
    XP_512382.3
828 aa
   DNM2,  M.mulatta
dynamin 2
    XP_001103119.1
870 aa
   DNM2,  C.lupus
dynamin 2
    XP_003639779.1
874 aa
   DNM2,  B.taurus
dynamin 2
    NP_001092839.1
866 aa
   Dnm2,  M.musculus
dynamin 2
    NP_001240822.1
870 aa
   Dnm2,  R.norvegicus
dynamin 2
    NP_037331.1
870 aa
   dnm2,  X.tropicalis
dynamin 2
    NP_001011076.1
867 aa
   dnm2b,  D.rerio
dynamin 2b
    NP_998407.1
856 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myopathy, centronuclear.
Charcot-Marie-Tooth disease, dominant intermediate 1.
Charcot-Marie-Tooth disease, dominant intermediate B.



Publications
Articles associated with genes and sequences of this homology group.

Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.
Koutsopoulos OS, et al. Eur J Hum Genet 21, 637-42 (2013).
Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.
Lee YY, et al. Eur J Obstet Gynecol Reprod Biol 164, 180-4 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GED (pfam02212)
  Dynamin GTPase effector domain.
Dynamin_M (pfam01031)
  Dynamin central region.
Dynamin_M (pfam01031)
  Dynamin central region.
ARS2 (pfam04959)
  Arsenite-resistance protein 2.
DAZAP2 (pfam11029)
  DAZ associated protein 2 (DAZAP2).
GED (cl02558)
  Dynamin GTPase effector domain.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dnm2 includes H.sapiens DNM2 and R.norvegicus Dnm2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (30 transcripts, 9 species)
Mammalia - mammals (18 transcripts, 12 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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