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HomoloGene:10318. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   MKKS,  H.sapiens
McKusick-Kaufman syndrome
570 aa
   MKKS,  P.troglodytes
McKusick-Kaufman syndrome
570 aa
   MKKS,  M.mulatta
McKusick-Kaufman syndrome
570 aa
   MKKS,  C.lupus
McKusick-Kaufman syndrome
570 aa
   MKKS,  B.taurus
McKusick-Kaufman syndrome
570 aa
   Mkks,  M.musculus
McKusick-Kaufman syndrome
570 aa
   Mkks,  R.norvegicus
McKusick-Kaufman syndrome
570 aa
   MKKS,  G.gallus
McKusick-Kaufman syndrome
570 aa
   mkks,  X.tropicalis
McKusick-Kaufman syndrome
572 aa
   mkks,  D.rerio
McKusick-Kaufman syndrome
563 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Bardet-Biedl syndrome 6.
McKusick-Kaufman syndrome.

Articles associated with genes and sequences of this homology group.

McKusick-Kaufman Syndrome
Slavotinek AM, et al. (1993).
Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome.
Fath MA, et al. Hum Mol Genet 14, 1109-18 (2005).
Mutations in MKKS cause Bardet-Biedl syndrome.
Slavotinek AM, et al. Nat Genet 26, 15-6 (2000).
Genetic and physical mapping of the McKusick-Kaufman syndrome.
Stone DL, et al. Hum Mol Genet 7, 475-81 (1998).
Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes.
Beyer AM, et al. Am J Physiol Heart Circ Physiol 299, H1902-7 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cpn60_TCP1 (pfam00118)
  TCP-1/cpn60 chaperonin family.
chaperonin_like (cl02777)
  chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mkks includes H.sapiens MKKS and R.norvegicus Mkks.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (13 transcripts, 10 species)
Aves - birds (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)




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