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HomoloGene:10318. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MKKS,  H.sapiens
McKusick-Kaufman syndrome
    NP_740754.1
570 aa
   MKKS,  P.troglodytes
McKusick-Kaufman syndrome
    XP_001169410.1
570 aa
   MKKS,  M.mulatta
McKusick-Kaufman syndrome
    XP_001116196.1
570 aa
   MKKS,  C.lupus
McKusick-Kaufman syndrome
    XP_542894.1
570 aa
   MKKS,  B.taurus
McKusick-Kaufman syndrome
    NP_001193100.1
570 aa
   Mkks,  M.musculus
McKusick-Kaufman syndrome
    NP_067502.2
570 aa
   Mkks,  R.norvegicus
McKusick-Kaufman syndrome
    NP_001008354.1
570 aa
   MKKS,  G.gallus
McKusick-Kaufman syndrome
    NP_001186339.1
570 aa
   mkks,  X.tropicalis
McKusick-Kaufman syndrome
    XP_002931783.1
572 aa
   mkks,  D.rerio
McKusick-Kaufman syndrome
    NP_956459.1
563 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Bardet-Biedl syndrome 6.
McKusick-Kaufman syndrome.



Publications
Articles associated with genes and sequences of this homology group.

McKusick-Kaufman Syndrome
Slavotinek AM, et al. (1993).
Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome.
Fath MA, et al. Hum Mol Genet 14, 1109-18 (2005).
Mutations in MKKS cause Bardet-Biedl syndrome.
Slavotinek AM, et al. Nat Genet 26, 15-6 (2000).
Genetic and physical mapping of the McKusick-Kaufman syndrome.
Stone DL, et al. Hum Mol Genet 7, 475-81 (1998).
Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes.
Beyer AM, et al. Am J Physiol Heart Circ Physiol 299, H1902-7 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cpn60_TCP1 (pfam00118)
  TCP-1/cpn60 chaperonin family.
chaperonin_like (cl02777)
  chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mkks includes H.sapiens MKKS and R.norvegicus Mkks.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Aves - birds (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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