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HomoloGene:1474. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TYMP,  H.sapiens
thymidine phosphorylase
482 aa
   TYMP,  P.troglodytes
thymidine phosphorylase
163 aa
   TYMP,  M.mulatta
thymidine phosphorylase
482 aa
   Tymp,  M.musculus
thymidine phosphorylase
471 aa
   Tymp,  R.norvegicus
thymidine phosphorylase
476 aa
   tymp,  X.tropicalis
thymidine phosphorylase
473 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Mitochondrial neurogastrointestinal encephalomyopathy syndrome.

Articles associated with genes and sequences of this homology group.

Prognostic value of TP/PD-ECGF and thrombocytosis in gastric carcinoma.
Wang L, et al. Eur J Surg Oncol 38, 568-73 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Glycos_trans_3N (pfam02885)
  Glycosyl transferase family, helical bundle domain.
Y_phosphoryl (TIGR02644)
  In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC, as in Bacillus subtilis, and more narrowly as the enzyme family EC, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff [Purines, pyrimidines, nucleosides, and nucleotides, Other].
PYNP_C (cl06734)
  This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as Escherichia coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Glycos_transf_3 (pfam00591)
  Glycosyl transferase family, a/b domain.
Glycos_trans_3N (pfam02885)
  Glycosyl transferase family, helical bundle domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tymp includes H.sapiens TYMP and R.norvegicus Tymp.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (5 transcripts, 5 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (1 transcript, 1 species)

Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Insecta - insects (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Turbellaria - flatworms (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)

Oligohymenophorea - ciliates (1 transcript, 1 species)

Monosiga - choanoflagellates (1 transcript, 1 species)




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