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HomoloGene:15604. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   DUSP16,  H.sapiens
dual specificity phosphatase 16
665 aa
   DUSP16,  P.troglodytes
dual specificity phosphatase 16
665 aa
   DUSP16,  M.mulatta
dual specificity phosphatase 16
665 aa
   DUSP16,  C.lupus
dual specificity phosphatase 16
663 aa
   DUSP16,  B.taurus
dual specificity phosphatase 16
643 aa
   Dusp16,  M.musculus
dual specificity phosphatase 16
660 aa
   Dusp16,  R.norvegicus
dual specificity phosphatase 16
661 aa
   DUSP16,  G.gallus
dual specificity phosphatase 16
664 aa
   dusp16,  X.tropicalis
dual specificity phosphatase 16
647 aa
   dusp16,  D.rerio
dual specificity phosphatase 16
539 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

MKP-7, a negative regulator of JNK, regulates VCAM-1 expression through IRF-1.
Nizamutdinova IT, et al. Cell Signal 24, 866-72 (2012).
Phosphorylation of Ser-446 determines stability of MKP-7.
Katagiri C, et al. J Biol Chem 280, 14716-22 (2005).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DSPc (cl00053)
  Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
RHOD (cl00125)
  Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dusp16 includes H.sapiens DUSP16 and R.norvegicus Dusp16.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (10 transcripts, 6 species)
Mammalia - mammals (8 transcripts, 8 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Arachnida - arachnids (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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