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HomoloGene:26175. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   WHSC1,  H.sapiens
Wolf-Hirschhorn syndrome candidate 1
1365 aa
   WHSC1,  P.troglodytes
Wolf-Hirschhorn syndrome candidate 1
1365 aa
   LOC712618,  M.mulatta
probable histone-lysine N-methyltransferase NSD2-like
713 aa
   WHSC1,  C.lupus
Wolf-Hirschhorn syndrome candidate 1
1364 aa
   WHSC1,  B.taurus
Wolf-Hirschhorn syndrome candidate 1
1365 aa
   Whsc1,  M.musculus
Wolf-Hirschhorn syndrome candidate 1 (human)
1366 aa
   Whsc1,  R.norvegicus
Wolf-Hirschhorn syndrome candidate 1
1346 aa
   WHSC1,  G.gallus
Wolf-Hirschhorn syndrome candidate 1
1395 aa
   whsc1,  X.tropicalis
Wolf-Hirschhorn syndrome candidate 1
1298 aa
   whsc1,  D.rerio
Wolf-Hirschhorn syndrome candidate 1
1461 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Wolf-Hirschhorn syndrome.

Articles associated with genes and sequences of this homology group.

Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.
Hajdu I, et al. Proc Natl Acad Sci U S A 108, 13130-4 (2011).
MMSET is highly expressed and associated with aggressiveness in neuroblastoma.
Hudlebusch HR, et al. Cancer Res 71, 4226-35 (2011).
Functional characterization of the zebrafish WHSC1-related gene, a homolog of human NSD2.
Yamada-Okabe T, et al. Biochem Biophys Res Commun 402, 335-9 (2010).
Wolf-Hirschhorn Syndrome
Battaglia A, et al. (1993).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AWS (smart00570)
  associated with SET domains.
PHD (pfam00628)
RING (cl15348)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
TNG2 (COG5034)
  Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics].
SRP-alpha_N (pfam04086)
  Signal recognition particle, alpha subunit, N-terminal.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
PWWP (cl02554)
  The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
SET (cl02566)
  SET domain.
PHD (cl17445)

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Whsc1 includes H.sapiens WHSC1 and R.norvegicus Whsc1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 9 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Aves - birds (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Insecta - insects (6 transcripts, 5 species)
Arachnida - arachnids (2 transcripts, 2 species)

Anthozoa - anthozoans (2 transcripts, 1 species)

Echinoidea - sea urchins (2 transcripts, 2 species)

Trematoda - flatworms (1 transcript, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)

Eudicotyledons - eudicots (5 transcripts, 4 species)
Bryopsida - mosses (1 transcript, 1 species)

Peronosporales - oomycetes (1 transcript, 1 species)

Monosiga - choanoflagellates (1 transcript, 1 species)




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