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HomoloGene:40908. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CNGB3,  H.sapiens
cyclic nucleotide gated channel beta 3
    NP_061971.3
809 aa
   CNGB3,  P.troglodytes
cyclic nucleotide gated channel beta 3
    XP_519846.2
809 aa
   CNGB3,  M.mulatta
cyclic nucleotide gated channel beta 3
    XP_001083646.1
808 aa
   CNGB3,  C.lupus
cyclic nucleotide gated channel beta 3
    NP_001003030.1
782 aa
   CNGB3,  B.taurus
cyclic nucleotide gated channel beta 3
    XP_002692873.2
770 aa
   Cngb3,  M.musculus
cyclic nucleotide gated channel beta 3
    NP_038955.1
694 aa
   Cngb3,  R.norvegicus
cyclic nucleotide gated channel beta 3
    NP_001258167.1
690 aa
   CNGB3,  G.gallus
cyclic nucleotide gated channel beta 3
    XP_425928.4
717 aa
   cngb3,  X.tropicalis
cyclic nucleotide gated channel beta 3
    XP_002939202.2
784 aa
   cngb3,  D.rerio
cyclic nucleotide gated channel beta 3
    XP_691142.4
857 aa
   LOC562466,  D.rerio
cyclic nucleotide-gated cation channel beta-3-like
    XP_690937.4
771 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Macular degeneration, juvenile.
Achromatopsia-3.



Publications
Articles associated with genes and sequences of this homology group.

Gene therapy rescues cone function in congenital achromatopsia.
Komáromy AM, et al. Hum Mol Genet 19, 2581-93 (2010).
Genetic heterogeneity of day blindness in Alaskan Malamutes.
Seddon JM, et al. Anim Genet 37, 407-10 (2006).
Progressive cone dystrophy associated with mutation in CNGB3.
Michaelides M, et al. Invest Ophthalmol Vis Sci 45, 1975-82 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
Ion_trans (pfam00520)
  Ion transport protein.
CAP_ED (cl00047)
  effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cngb3 includes H.sapiens CNGB3 and R.norvegicus Cngb3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (6 transcripts, 4 species)
Mammalia - mammals (5 transcripts, 5 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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