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HomoloGene:233. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OCRL,  H.sapiens
oculocerebrorenal syndrome of Lowe
    NP_000267.2
901 aa
   OCRL,  P.troglodytes
oculocerebrorenal syndrome of Lowe
    XP_003317719.2
883 aa
   OCRL,  M.mulatta
oculocerebrorenal syndrome of Lowe
    XP_002806438.1
901 aa
   OCRL,  C.lupus
oculocerebrorenal syndrome of Lowe
    XP_852376.2
902 aa
   OCRL,  B.taurus
oculocerebrorenal syndrome of Lowe
    NP_001095661.1
784 aa
   Ocrl,  M.musculus
oculocerebrorenal syndrome of Lowe
    NP_796189.2
900 aa
   Ocrl,  R.norvegicus
oculocerebrorenal syndrome of Lowe
    NP_001101726.2
899 aa
   OCRL,  G.gallus
oculocerebrorenal syndrome of Lowe
    XP_004940632.1
931 aa
   ocrl,  X.tropicalis
oculocerebrorenal syndrome of Lowe
    XP_004919252.1
909 aa
   ocrl,  D.rerio
oculocerebrorenal syndrome of Lowe
    NP_001071232.1
952 aa
   LOC100329312,  D.rerio
inositol polyphosphate 5-phosphatase OCRL-1-like
    XP_003199958.1
953 aa
   Ocrl,  D.melanogaster
Oculocerebrorenal syndrome of Lowe 1 ortholog
    NP_569962.2
850 aa
   AgaP_AGAP010556,  A.gambiae
AgaP_AGAP010556
    XP_558090.3
876 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dent syndrome.
Lowe syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Lowe syndrome: Between primary cilia assembly and Rac1-mediated membrane remodeling.
Madhivanan K, et al. Commun Integr Biol 5, 641-4 (2012).
Novel OCRL mutations in Chinese children with Lowe syndrome.
Zhang YQ, et al. World J Pediatr 9, 53-7 (2013).
Duplication of OCRL and adjacent genes associated with autism but not Lowe syndrome.
Schroer RJ, et al. Am J Med Genet A 158A, 2602-5 (2012).
[Genetic testing in a Chinese pedigree with Lowe syndrome].
Hua R, et al. Zhonghua Yan Ke Za Zhi 47, 801-5 (2011).
Recognition of the F&H motif by the Lowe syndrome protein OCRL.
Pirruccello M, et al. Nat Struct Mol Biol 18, 789-95 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EEP (cl00490)
  Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily.
Trp-synth-beta_II (cl00342)
  Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
EEP (cl00490)
  Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ocrl includes H.sapiens OCRL and R.norvegicus Ocrl.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 3 species)
Arachnida - arachnids (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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