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HomoloGene:4987. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SPINK5,  H.sapiens
serine peptidase inhibitor, Kazal type 5
    NP_001121170.1
1094 aa
   SPINK5,  P.troglodytes
serine peptidase inhibitor, Kazal type 5
    XP_001160618.1
1094 aa
   SPINK5,  M.mulatta
serine peptidase inhibitor, Kazal type 5
    XP_001103296.1
1087 aa
   SPINK5,  C.lupus
serine peptidase inhibitor, Kazal type 5
    NP_001020568.1
1063 aa
   SPINK5,  B.taurus
serine peptidase inhibitor, Kazal type 5
    NP_001095572.1
1091 aa
   Spink5,  M.musculus
serine peptidase inhibitor, Kazal type 5
    NP_001074649.1
1017 aa
   Spink5,  R.norvegicus
serine peptidase inhibitor, Kazal type 5
    NP_001164077.1
1019 aa
   LOC100910851,  R.norvegicus
serine protease inhibitor Kazal-type 5-like
    XP_003749120.1
1019 aa
   SPINK5,  G.gallus
serine peptidase inhibitor, Kazal type 5 (ovoinhibitor)
    XP_004944964.1
517 aa
   SPINK7,  G.gallus
serine peptidase inhibitor, Kazal type 7 (putative)
    NP_001106132.1
208 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Atopy.
Netherton syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Low SPINK5 expression in chronic rhinosinusitis.
Fruth K, et al. Laryngoscope 122, 1198-204 (2012).
Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China.
Zhao LP, et al. J Eur Acad Dermatol Venereol 26, 572-7 (2012).
A new SPINK5 donor splice site mutation in siblings with Netherton syndrome.
Tüysüz B, et al. Acta Derm Venereol 90, 95-6 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Kazal_2 (pfam07648)
  Kazal-type serine protease inhibitor domain.
Kazal_1 (pfam00050)
  Kazal-type serine protease inhibitor domain.
KAZAL_FS (cl00097)
  Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
KAZAL_FS (cl00097)
  Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Spink5 includes H.sapiens SPINK5 and R.norvegicus Spink5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)

 

 

 

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