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HomoloGene:4558. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   PROP1,  H.sapiens
PROP paired-like homeobox 1
226 aa
   PROP1,  P.troglodytes
PROP paired-like homeobox 1
226 aa
   PROP1,  C.lupus
PROP paired-like homeobox 1
226 aa
   PROP1,  B.taurus
PROP paired-like homeobox 1
226 aa
   Prop1,  M.musculus
paired like homeodomain factor 1
223 aa
   Prop1,  R.norvegicus
PROP paired-like homeobox 1
223 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Pituitary hormone deficiency, combined.

Articles associated with genes and sequences of this homology group.

Aged PROP1 deficient dwarf mice maintain ACTH production.
Nasonkin IO, et al. PLoS One 6, e28355 (2011).
Mutations and pituitary morphology in a series of 82 patients with PROP1 gene defects.
Obermannova B, et al. Horm Res Paediatr 76, 348-54 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prop1 includes H.sapiens PROP1 and R.norvegicus Prop1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Chromadorea - nematodes (1 transcript, 1 species)




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