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HomoloGene:2968. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PAX2,  H.sapiens
paired box 2
    NP_000269.2
393 aa
   PAX2,  P.troglodytes
paired box 2
    XP_001168808.2
394 aa
   PAX2,  M.mulatta
paired box 2
    XP_001108817.2
394 aa
   PAX2,  C.lupus
paired box 2
    XP_005637679.1
363 aa
   PAX2,  B.taurus
paired box 2
    XP_005225730.1
571 aa
   Pax2,  M.musculus
paired box 2
    NP_035167.4
394 aa
   Pax2,  R.norvegicus
paired box 2
    NP_001099831.1
416 aa
   PAX2,  G.gallus
paired box 2
    NP_990124.1
394 aa
   pax2a,  D.rerio
paired box gene 2a
    NP_571259.1
391 aa
   pax2b,  D.rerio
paired box gene 2b
    NP_571715.1
386 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Optic nerve coloboma with renal disease.
Renal hypoplasia, isolated.



Publications
Articles associated with genes and sequences of this homology group.

Papillorenal syndrome in a family with unusual complications.
Megaw RD, et al. Br J Ophthalmol 97, 945-6 (2013).
Expression pattern of PAX2 in hyperplastic and malignant endometrium.
Kahraman K, et al. Arch Gynecol Obstet 286, 173-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pax2_C (pfam12403)
  Paired-box protein 2 C terminal.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Pax2_C (pfam12403)
  Paired-box protein 2 C terminal.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
PAX (cl19075)
  Paired Box domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pax2 includes H.sapiens PAX2 and R.norvegicus Pax2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

 

 

 

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