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HomoloGene:10257. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DISC1,  H.sapiens
disrupted in schizophrenia 1
    NP_001158009.1
886 aa
   DISC1,  P.troglodytes
disrupted in schizophrenia 1
    XP_003308861.1
890 aa
   DISC1,  M.mulatta
disrupted in schizophrenia 1
    NP_001107827.1
854 aa
   DISC1,  C.lupus
disrupted in schizophrenia 1
    XP_546088.3
848 aa
   DISC1,  B.taurus
disrupted in schizophrenia 1
    XP_002698851.2
507 aa
   Disc1,  M.musculus
disrupted in schizophrenia 1
    NP_777279.2
852 aa
   Disc1,  R.norvegicus
disrupted in schizophrenia 1
    NP_783186.2
824 aa
   DISC1,  G.gallus
disrupted in schizophrenia 1
    XP_003641003.2
862 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Schizoaffective disorder, susceptibility to.
Schizophrenia, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Revisiting disrupted-in-schizophrenia 1 as a scaffold protein.
Yerabham AS, et al. Biol Chem 394, 1425-37 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Smc (COG1196)
  Chromosome segregation ATPases [Cell division and chromosome partitioning].
SMC_prok_B (TIGR02168)
  chromosome segregation protein SMC, common bacterial type.
SMC_prok_A (TIGR02169)
  chromosome segregation protein SMC, primarily archaeal type.
Prefoldin (cl09111)
  Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Disc1 includes H.sapiens DISC1 and R.norvegicus Disc1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 4 species)

 

 

 

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