Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:2016. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   POLG,  H.sapiens
polymerase (DNA directed), gamma
    NP_001119603.1
1239 aa
   POLG,  P.troglodytes
polymerase (DNA directed), gamma
    XP_523149.2
1236 aa
   POLG,  M.mulatta
polymerase (DNA directed), gamma
    XP_001092360.1
1228 aa
   POLG,  C.lupus
polymerase (DNA directed), gamma
    XP_005618410.1
1241 aa
   POLG,  B.taurus
polymerase (DNA directed), gamma
    XP_002696610.2
1248 aa
   Polg,  M.musculus
polymerase (DNA directed), gamma
    NP_059490.2
1217 aa
   Polg,  R.norvegicus
polymerase (DNA directed), gamma
    NP_445980.1
1216 aa
   POLG,  G.gallus
polymerase (DNA directed), gamma
    XP_425079.4
929 aa
   LOC100488393,  X.tropicalis
DNA polymerase subunit gamma-1-like
    XP_002932281.2
1197 aa
   polg,  D.rerio
polymerase (DNA directed), gamma
    XP_001921130.3
1206 aa
   tam,  D.melanogaster
tamas
    NP_476821.1
1145 aa
   AgaP_AGAP000139,  A.gambiae
AgaP_AGAP000139
    XP_311006.5
1161 aa
   MIP1,  S.cerevisiae
MIP1
    NP_014975.2
1254 aa
   AGOS_ADR357C,  E.gossypii
AGOS_ADR357C
    NP_984453.1
1131 aa
   pog1,  S.pombe
pog1
    NP_588025.2
1018 aa
   MGG_08913,  M.oryzae
MGG_08913
    XP_003713942.1
1147 aa
   NCU00276,  N.crassa
NCU00276
    XP_957747.2
1456 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Progressive external ophthalmoplegia with mitochondrial DNA deletions.
Alpers syndrome.
Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis.
Spinocerebellar ataxia with epilepsy.



Publications
Articles associated with genes and sequences of this homology group.

Mitochondrial regulation in pluripotent stem cells.
Xu X, et al. Cell Metab 18, 325-32 (2013).
The clinical and audiologic features of hearing loss due to mitochondrial mutations.
Yelverton JC, et al. Otolaryngol Head Neck Surg 148, 1017-22 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DNA_pol_A (cl02626)
  Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication.
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.
DNA_pol_A (cl02626)
  Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication.
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Polg includes H.sapiens POLG and R.norvegicus Polg.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Ascidiacea - tunicates (3 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

Write to the Help Desk