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HomoloGene:1550. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GATA3,  H.sapiens
GATA binding protein 3
    NP_002042.1
443 aa
   GATA3,  P.troglodytes
GATA binding protein 3
    XP_507651.1
444 aa
   GATA3,  M.mulatta
GATA binding protein 3
    XP_001108337.1
444 aa
   GATA3,  C.lupus
GATA binding protein 3
    XP_849153.1
444 aa
   GATA3,  B.taurus
GATA binding protein 3
    NP_001070272.1
443 aa
   Gata3,  M.musculus
GATA binding protein 3
    NP_032117.1
443 aa
   Gata3,  R.norvegicus
GATA binding protein 3
    NP_579827.1
444 aa
   GATA3,  G.gallus
GATA binding protein 3
    NP_001008444.1
444 aa
   gata3,  X.tropicalis
GATA binding protein 3
    NP_001004967.1
437 aa
   gata3,  D.rerio
GATA-binding protein 3
    NP_571286.1
438 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypoparathyroidism, sensorineural deafness, and renal dysplasia.



Publications
Articles associated with genes and sequences of this homology group.

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.
Frelin C, et al. Nat Immunol 14, 1037-44 (2013).
Value of GATA3 immunostaining in tumor diagnosis: a review.
Ordóñez NG. Adv Anat Pathol 20, 352-60 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ZnF_GATA (cl00158)
  Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gata3 includes H.sapiens GATA3 and R.norvegicus Gata3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (13 transcripts, 7 species)
Mammalia - mammals (11 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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