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HomoloGene:30982. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COMT,  H.sapiens
catechol-O-methyltransferase
    NP_001128633.1
271 aa
   COMT,  P.troglodytes
catechol-O-methyltransferase
    XP_514984.2
309 aa
   COMT,  M.mulatta
catechol-O-methyltransferase
    XP_001105683.1
270 aa
   COMT,  C.lupus
catechol-O-methyltransferase
    NP_001004074.1
221 aa
   COMT,  B.taurus
catechol-O-methyltransferase
    NP_001095787.1
272 aa
   Comt,  M.musculus
catechol-O-methyltransferase
    NP_001104532.1
265 aa
   Comt,  R.norvegicus
catechol-O-methyltransferase
    NP_036663.1
264 aa
   COMT,  G.gallus
catechol-O-methyltransferase
    XP_001233014.1
262 aa
   comt,  X.tropicalis
catechol-O-methyltransferase
    NP_001016357.1
261 aa
   comt.2,  X.tropicalis
catechol-O-methyltransferase
    NP_001017157.1
216 aa
   LOC100135405,  X.tropicalis
uncharacterized LOC100135405
    NP_001107540.1
214 aa
   SPBPB21E7.04c,  S.pombe
SPBPB21E7.04c
    NP_001018770.1
281 aa
   SPBC119.03,  S.pombe
SPBC119.03
    NP_595284.1
266 aa
   MGG_00015,  M.oryzae
MGG_00015
    XP_003719132.1
266 aa
   NCU07919,  N.crassa
NCU07919
    XP_962435.2
246 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Panic disorder, susceptibility to.
Schizophrenia, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Catechol-O-methyltransferase activity in psoriasis patients treated with psoralen plus ultraviolet A therapy.
Souteiro P, et al. Photodermatol Photoimmunol Photomed 29, 227-32 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Methyltransf_24 (pfam13578)
  Methyltransferase domain.
AdoMet_MTases (cl17173)
  S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Comt includes H.sapiens COMT.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Ascidiacea - tunicates (6 transcripts, 2 species)
Amphibia - amphibians (5 transcripts, 2 species)
Cephalochordata - lancelets (3 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)

Streptophyta
Coniferopsida - conifers (4 transcripts, 2 species)
Liliopsida - monocots (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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