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HomoloGene:1980. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PHB,  H.sapiens
prohibitin
    NP_001268425.1
272 aa
   PHB,  P.troglodytes
prohibitin
    NP_001233332.1
272 aa
   PHB,  M.mulatta
prohibitin
    XP_001093453.1
272 aa
   PHB,  C.lupus
prohibitin
    NP_001103649.1
272 aa
   PHB,  B.taurus
prohibitin
    NP_001029744.1
272 aa
   Phb,  M.musculus
prohibitin
    NP_032857.1
272 aa
   Phb,  R.norvegicus
prohibitin
    NP_114039.1
272 aa
   PHB,  G.gallus
prohibitin
    NP_001171206.1
272 aa
   phb,  X.tropicalis
prohibitin
    NP_989038.1
272 aa
   phb,  D.rerio
prohibitin
    NP_958454.1
271 aa
   l(2)37Cc,  D.melanogaster
lethal (2) 37Cc
    NP_724165.1
276 aa
   AgaP_AGAP009323,  A.gambiae
AgaP_AGAP009323
    XP_309992.2
272 aa
   phb-1,  C.elegans
phb-1
    NP_490929.1
275 aa
   PHB1,  S.cerevisiae
PHB1
    NP_011648.3
287 aa
   KLLA0D16302g,  K.lactis
KLLA0D16302g
    XP_453779.1
226 aa
   AGOS_AFR313C,  E.gossypii
AGOS_AFR313C
    NP_985860.1
283 aa
   phb1,  S.pombe
phb1
    NP_594713.1
282 aa
   MGG_06004,  M.oryzae
MGG_06004
    XP_003711850.1
275 aa
   NCU08946,  N.crassa
NCU08946
    XP_960813.2
269 aa
   PHB4,  A.thaliana
PHB4
    NP_189364.1
279 aa
   PHB3,  A.thaliana
PHB3
    NP_198893.1
277 aa
   Os02g0580500,  O.sativa
Os02g0580500
    NP_001047236.1
282 aa
   Os04g0462900,  O.sativa
Os04g0462900
    NP_001053006.2
296 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Many different complementing heteroallelic genotypes exhibit opaque wings, often incompletely expanded, moderate Minute-like bristles and a lighter tan body color.

H.sapiens
Breast cancer, sporadic.



Publications
Articles associated with genes and sequences of this homology group.

Signaling pathways of prohibitin and its role in diseases.
Zhou TB & Qin YH. J Recept Signal Transduct Res 33, 28-36 (2013).
Identification of prohibitin as a Chikungunya virus receptor protein.
Wintachai P, et al. J Med Virol 84, 1757-70 (2012).
Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury.
Sánchez-Quiles V, et al. J Proteomics 75, 5783-92 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Band_7_prohibitin (cd03401)
  Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may ...
SPFH_like (cl19107)
  core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Phb includes H.sapiens PHB and R.norvegicus Phb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (24 transcripts, 15 species)
Actinopterygii - bony fishes (12 transcripts, 11 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Aves - birds (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 13 species)
Arachnida - arachnids (4 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (59 transcripts, 34 species)
Liliopsida - monocots (14 transcripts, 7 species)
Coniferopsida - conifers (7 transcripts, 3 species)
Bryopsida - mosses (3 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (11 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (5 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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