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HomoloGene:25090. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SVIL,  H.sapiens
supervillin
    NP_068506.2
2214 aa
   SVIL,  P.troglodytes
supervillin
    XP_001136112.1
2214 aa
   SVIL,  M.mulatta
supervillin
    XP_001083894.2
2299 aa
   SVIL,  C.lupus
supervillin
    XP_005617106.1
2287 aa
   SVIL,  B.taurus
supervillin
    NP_776615.1
1792 aa
   Svil,  M.musculus
supervillin
    NP_694793.1
2170 aa
   Svil,  R.norvegicus
supervillin
    NP_001101886.2
2165 aa
   SVIL,  G.gallus
supervillin
    XP_004939254.1
2304 aa
   svil,  X.tropicalis
supervillin
    NP_001090765.1
1771 aa
   svila,  D.rerio
supervillin a
    NP_001030338.2
1763 aa
   svilb,  D.rerio
supervillin b
    XP_003197996.2
2790 aa
   CG33232,  D.melanogaster
CG33232
    NP_995968.1
1266 aa
   AgaP_AGAP007181,  A.gambiae
AgaP_AGAP007181
    XP_565017.3
1210 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

F-actin and myosin II binding domains in supervillin.
Chen Y, et al. J Biol Chem 278, 46094-106 (2003).
Villin-type headpiece domains show a wide range of F-actin-binding affinities.
Vardar D, et al. Cell Motil Cytoskeleton 52, 9-21 (2002).
Supervillin-mediated suppression of p53 protein enhances cell survival.
Fang Z & Luna EJ. J Biol Chem 288, 7918-29 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Rb_C (pfam08934)
  Rb C-terminal domain.
VHP (cl02491)
  Villin headpiece domain.
ADF_gelsolin (cl15697)
  Actin depolymerization factor/cofilin- and gelsolin-like domains.
ADF_gelsolin (cl15697)
  Actin depolymerization factor/cofilin- and gelsolin-like domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Svil includes H.sapiens SVIL and R.norvegicus Svil.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 10 species)
Mammalia - mammals (18 transcripts, 13 species)
Aves - birds (6 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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