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HomoloGene:4539. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   POLE,  H.sapiens
polymerase (DNA directed), epsilon, catalytic subunit
    NP_006222.2
2286 aa
   POLE,  P.troglodytes
polymerase (DNA directed), epsilon
    XP_522564.4
829 aa
   POLE,  C.lupus
polymerase (DNA directed), epsilon, catalytic subunit
    XP_543348.3
2237 aa
   POLE,  B.taurus
polymerase (DNA directed), epsilon, catalytic subunit
    NP_001178358.1
2289 aa
   Pole,  M.musculus
polymerase (DNA directed), epsilon
    NP_035262.2
2283 aa
   Pole,  R.norvegicus
polymerase (DNA directed), epsilon, catalytic subunit
    NP_001100622.2
2283 aa
   POLE,  G.gallus
polymerase (DNA directed), epsilon, catalytic subunit
    XP_004934482.1
2309 aa
   pole,  X.tropicalis
polymerase (DNA directed), epsilon, catalytic subunit
    XP_004910692.1
2286 aa
   pole,  D.rerio
polymerase (DNA directed), epsilon
    NP_001121995.1
2284 aa
   DNApol-epsilon,  D.melanogaster
DNA polymerase epsilon
    NP_524462.2
2236 aa
   AgaP_AGAP004615,  A.gambiae
AgaP_AGAP004615
    XP_315205.4
2219 aa
   F33H2.5,  C.elegans
F33H2.5
    NP_493616.1
2144 aa
   POL2,  S.cerevisiae
POL2
    NP_014137.1
2222 aa
   KLLA0C02585g,  K.lactis
KLLA0C02585g
    XP_452312.1
2185 aa
   AGOS_AFR657C,  E.gossypii
AGOS_AFR657C
    NP_986205.2
2180 aa
   cdc20,  S.pombe
cdc20
    NP_596354.1
2199 aa
   MGG_03850,  M.oryzae
MGG_03850
    XP_003720041.1
2240 aa
   NCU04548,  N.crassa
NCU04548
    XP_955939.2
2262 aa
   TIL2,  A.thaliana
TIL2
    NP_180280.2
2138 aa
   TIL1,  A.thaliana
TIL1
    NP_172303.5
2161 aa
   Os02g0511900,  O.sativa
Os02g0511900
    NP_001046939.2
2175 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Kinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ε.
Zahurancik WJ, et al. Biochemistry 52, 7041-9 (2013).
Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer.
Zhou Q, et al. Cancer Genomics Proteomics 5, 287-92 (2008).
H2B-K123 ubiquitination stimulates RNAPII elongation independent of H3-K4 methylation.
Shukla A & Bhaumik SR. Biochem Biophys Res Commun 359, 214-20 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cornifin (pfam02389)
  Cornifin (SPRR) family.
DUF1744 (pfam08490)
  Domain of unknown function (DUF1744).
COG1933 (COG1933)
  Archaeal DNA polymerase II, large subunit [DNA replication, recombination, and repair]
POLBc (cl10023)
  DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both ...
DNA_pol_B_exo1 (pfam03104)
  DNA polymerase family B, exonuclease domain.
DUF1744 (pfam08490)
  Domain of unknown function (DUF1744).
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pole includes H.sapiens POLE and R.norvegicus Pole.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (25 transcripts, 13 species)
Liliopsida - monocots (9 transcripts, 5 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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