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HomoloGene:975. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHEK1,  H.sapiens
checkpoint kinase 1
    NP_001265.2
476 aa
   CHEK1,  P.troglodytes
checkpoint kinase 1
    XP_001146296.1
476 aa
   LOC713358,  M.mulatta
serine/threonine-protein kinase Chk1-like
    XP_001111431.2
743 aa
   CHEK1,  C.lupus
checkpoint kinase 1
    XP_852191.1
460 aa
   CHEK1,  B.taurus
CHK1 checkpoint homolog (S. pombe)
    NP_001091492.1
476 aa
   Chek1,  M.musculus
checkpoint kinase 1
    NP_031717.2
476 aa
   Chek1,  R.norvegicus
checkpoint kinase 1
    NP_536325.1
476 aa
   STT3A,  G.gallus
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
    NP_989676.1
476 aa
   chek1,  X.tropicalis
checkpoint kinase 1
    XP_002937561.2
474 aa
   chek1,  D.rerio
CHK1 checkpoint homolog (S. pombe)
    NP_956487.1
410 aa
   grp,  D.melanogaster
grapes
    NP_723986.1
512 aa
   AgaP_AGAP008118,  A.gambiae
AgaP_AGAP008118
    XP_317338.4
505 aa
   chk-1,  C.elegans
chk-1
    NP_001024233.1
503 aa
   CHK1,  S.cerevisiae
CHK1
    NP_009833.1
527 aa
   KLLA0F01276g,  K.lactis
KLLA0F01276g
    XP_455137.1
519 aa
   AGOS_AEL185C,  E.gossypii
AGOS_AEL185C
    NP_984676.1
515 aa
   chk1,  S.pombe
chk1
    NP_588070.1
496 aa
   MGG_03729,  M.oryzae
MGG_03729
    XP_003716151.1
551 aa
   NCU08346,  N.crassa
NCU08346
    XP_965249.2
594 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Chk1 is essential for the development of murine epidermal melanocytes.
Smith J, et al. Pigment Cell Melanoma Res 26, 580-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Pkinase (pfam00069)
  Protein kinase domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chek1 includes H.sapiens CHEK1 and R.norvegicus Chek1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (2 transcripts, 2 species)
Eudicotyledons - eudicots (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)

 

 

 

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