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HomoloGene:55953. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NDRG1,  H.sapiens
N-myc downstream regulated 1
    NP_001128714.1
394 aa
   NDRG1,  P.troglodytes
N-myc downstream regulated 1
    XP_001140704.1
394 aa
   NDRG1,  M.mulatta
N-myc downstream regulated 1
    XP_001088640.1
394 aa
   NDRG1,  C.lupus
N-myc downstream regulated 1
    XP_005628031.1
384 aa
   NDRG1,  B.taurus
N-myc downstream regulated 1
    NP_001030181.1
384 aa
   Ndrg1,  M.musculus
N-myc downstream regulated gene 1
    NP_032707.2
394 aa
   Ndrg1,  R.norvegicus
N-myc downstream regulated 1
    NP_001011991.1
394 aa
   NDRG1,  G.gallus
N-myc downstream regulated 1
    XP_418430.2
402 aa
   ndrg1,  X.tropicalis
N-myc downstream regulated 1
    NP_001008146.1
395 aa
   ndrg1a,  D.rerio
N-myc downstream regulated gene 1a
    NP_998513.2
392 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Charcot-Marie-Tooth disease, type 4D.



Publications
Articles associated with genes and sequences of this homology group.

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.
Weiler M, et al. Proc Natl Acad Sci U S A 111, 409-14 (2014).
Low NDRG1 mRNA expression predicts a poor prognosis in neuroblastoma patients.
Matsushita K, et al. Pediatr Surg Int 29, 363-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ndr (pfam03096)
  Ndr family.
Transformer (pfam06495)
  Fruit fly transformer protein.
Hydrolase_4 (cl19140)
  Putative lysophospholipase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ndrg1 includes H.sapiens NDRG1 and R.norvegicus Ndrg1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 9 species)
Mammalia - mammals (12 transcripts, 11 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (23 transcripts, 19 species)
Bryopsida - mosses (3 transcripts, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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