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HomoloGene:21151. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ATP8B1,  H.sapiens
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    NP_005594.1
1251 aa
   ATP8B1,  P.troglodytes
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    XP_001139654.3
1247 aa
   ATP8B1,  M.mulatta
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    XP_002800987.1
1256 aa
   ATP8B1,  C.lupus
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    XP_533394.4
1267 aa
   ATP8B1,  B.taurus
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    NP_001179768.1
1251 aa
   Atp8b1,  M.musculus
ATPase, class I, type 8B, member 1
    NP_001001488.2
1251 aa
   Atp8b1,  R.norvegicus
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    NP_001099610.1
1259 aa
   ATP8B1,  G.gallus
ATPase, class I, type 8B, member 1
    NP_001264704.1
1249 aa
   atp8b1,  X.tropicalis
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    NP_001025562.1
1250 aa
   atp8b1,  D.rerio
ATPase, aminophospholipid transporter, class I, type 8B, member 1
    XP_001920510.4
1249 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cholestasis, progressive familial intrahepatic 1.
Cholestasis, benign recurrent intrahepatic.



Publications
Articles associated with genes and sequences of this homology group.

Heterozygous FIC1 deficiency: a new genetic predisposition to transient neonatal cholestasis.
Jacquemin E, et al. J Pediatr Gastroenterol Nutr 50, 447-9 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
COG4087 (COG4087)
  Soluble P-type ATPase [General function prediction only].
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
SLC5-6-like_sbd (cl00456)
  Solute carrier families 5 and 6-like; solute binding domain.
HAD (cl19137)
  haloacid dehalogenase-like hydrolase.
Acyl_transf_3 (cl19154)
  Acyltransferase family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Atp8b1 includes H.sapiens ATP8B1 and R.norvegicus Atp8b1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 7 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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