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HomoloGene:3137. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC9A3R1,  H.sapiens
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
    NP_004243.1
358 aa
   SLC9A3R1,  P.troglodytes
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
    XP_511663.2
358 aa
   SLC9A3R1,  M.mulatta
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
    XP_001092275.2
358 aa
   SLC9A3R1,  C.lupus
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
    XP_540418.4
366 aa
   SLC9A3R1,  B.taurus
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
    NP_001071320.1
368 aa
   Slc9a3r1,  M.musculus
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
    NP_036160.1
355 aa
   Slc9a3r1,  R.norvegicus
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
    NP_067605.1
356 aa
   SLC9A3R1,  G.gallus
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
    NP_001006424.1
333 aa
   slc9a3r1,  X.tropicalis
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
    NP_001006751.1
320 aa
   LOC100329719,  D.rerio
Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like
    XP_005174596.1
373 aa
   slc9a3r1,  D.rerio
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
    NP_997872.1
386 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Nephrolithiasis/osteoporosis, hypophosphatemic, 2.



Publications
Articles associated with genes and sequences of this homology group.

Ligand-induced dynamic changes in extended PDZ domains from NHERF1.
Bhattacharya S, et al. J Mol Biol 425, 2509-28 (2013).
NHERF-1 regulation of EGF and neurotensin signalling in HT-29 epithelial cells.
Kruger WA, et al. Biochem Biophys Res Commun 432, 568-73 (2013).
Involvement of nuclear NHERF1 in colorectal cancer progression.
Mangia A, et al. Oncol Rep 28, 889-94 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EBP50_C-term (pfam09007)
  EBP50, C-terminal.
EBP50_C-term (pfam09007)
  EBP50, C-terminal.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc9a3r1 includes H.sapiens SLC9A3R1 and R.norvegicus Slc9a3r1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 13 species)
Actinopterygii - bony fishes (7 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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